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literature on urgency  

ESSIC uses the name bladder pain syndrome (BPS) instead of interstitial cystitis (IC) and/or painful bladder syndrome (PBS):
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  • Two types of urgency.
    Blaivas JG, Panagopoulos G, Weiss JP, Somaroo C. Neurourol Urodyn 2009;28:188-90.
    - the definition of urgency remains the subject of much controversy
    - the authors believe that urgency is comprised of at least two different sensations
    - distinction between them is important since they may have different etiologies and may respond differently to treatment
  • Evaluation of urgency in women, with a validated Urgency, Severity and Impact Questionnaire (USIQ).
    Lowenstein L, Fitzgerald MP, Kenton K, et al. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Nov 20. [Epub ahead of print] PMID: 19020786
    • the aim of this study was to develop and validate a urinary urgency questionnaire to measure the severity and quality of life (QOL) impact from urinary urgency, in order to advance the clinical understanding of urinary urgency, and ultimately to guide the evaluation and treatment of patients with OAB
    • the USIQ comprises five symptom severity items and eight QOL items
    • click the title above for the full article (it is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited)
  • Assessing urgency in interstitial cystitis/painful bladder syndrome.   
    Diggs C, Meyer WA, Langenberg P, et al. Urology 2007;69:210-4
    • the O'Leary-Sant Symptom Index appeared to underreport urgency
    • asking about urgency "with little or no warning" underestimated the prevalence and degree of urinary urgency
    • the authors conclude with the question that may have pathophysiological importance: "why do patients with IC/PBS have urgency?"

  • The molecular basis of urgency: Regional difference of vanilloid receptor expression in the human urinary bladder.
    Liu L, Mansfield KJ, Kristiana I, et al. Neurourol Urodyn 2006 Oct 2; [Epub ahead of print]
    • the authors conclude that symptoms of sensory urgency were associated with the increased expression of targeting vanilloid receptor TRPV1 mRNA in the trigonal mucosa; no upregulation or regional differences of TRPV1 mRNA were seen in idiopathic detrusor overactivity patients
    • TRPV1 may play a role in SU and premature first bladder sensation on filling
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